I use CO2, in a closed/sealed grow room and sometimes I wish I'm not. Reason being unless everything is going perfectly it's a waste of money. Regular air has a CO2 level of 400ppm and with a sealed room and adding CO2 you can triple that. However unless your light, humidity, air flow and nutrients (pH, EC, nute profile), strains, etc are ALL 100% there's no point in adding more CO2 really. You're better off getting all the basics perfect first, then once that's done, thinking about adding CO2 last.