I don't think you need to prune anything as far as defoliation but you could trim the lowers a bit. You do need to make sure you have adequate air flow to minimize the risk of mold but keeping your temperature and humidity constant is a larger help. Large, 15+ swings in either direction can cause mold.
You could defoliate but that is removing your solar panels and adding unnecessary stress. Trimming afew inches from the bottom up where larfy weed will grow anyway would be the extent of it for me. Also your past the stretch, I think you could super crop branches out of the way but I don't think you need to do anything else at this point.