Looks like it could be a calcium deficiency but to make a proper determination we will need more information. Type of soil being used, lights, temperature, what nutrients at what strength and how often, pH of feeds, pH of run off. Deficiencies can be caused by a lack of nutrients or a nutrient lock out caused by the pH being out of range. Also, pictures of the whole plant, taken in natural light so we can see the true color of the leaves.