I think with that combo, parallel is your only option. Parallel gets you 6000ma max current handling at the 54v of the driver so the drivers 4900ma won’t hurt. Parallel is always considered a bit more risky, thermal runaway and all that, but I’ve read that the HLG qb288s are beasts and should be able to handle. I’ve have some HLG qb288s but they are wired in series with a different driver.