Thank for this. I had read that when it was new, but when I last looked the old paper came up... propbably just needed to scroll a bit further.
Cannabis Hyperemesis Syndrome
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I hope u never do either, definitely not fun. Pretty much feels like ur dieing.My suspicions precisely. However the question remains, why does this change in the receptors cause the symptoms, especially the unremitting puking? Does the opiod research discuss this aspect of the effect?
I use concentrate daily now, not all day, just eveniing and bedtime, so have been watching this issue carefully. Would be an absolute bugger, I hope I never see it.
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I do have a ph meter.Or simply lack of circulation .. then blood being drawn to the area by the hot water action..you know my theory about nerve pain being caused basically by lack of circulation...all considerations.
@Jean-O ...you haven't got a pH meter have you...?..
You know i take Gabapentin for my nerve pain quite strong doses and it does nothing for me when im sick. Its a nerve blocking pain med also used for anxiety.
My aunt before she passed would give me valume and that usually snapped me right out of being sick.
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Gabapentin did nowt for me..I had to start on 100mg and work up 100 mg a day to 1800mg but the pain just caught up with it..and hubby was scared of me on it..he said I was manic...
...sitting typing on speed and looking at him...smiling...... it frightened him..
Anyway..do this one on me on Trust...piss in a cup first thing..stick your PH pen in and let me know the reading.
You've got the kit..cost nowt to try..and May help find out what is going on...might be a total shot in the dark..
..
Just rinse the probe under running water..and it'll be fine again for your plants,
...sitting typing on speed and looking at him...smiling...... it frightened him..Anyway..do this one on me on Trust...piss in a cup first thing..stick your PH pen in and let me know the reading.
You've got the kit..cost nowt to try..and May help find out what is going on...might be a total shot in the dark..
..Just rinse the probe under running water..and it'll be fine again for your plants,
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Finally have a few minutes to sit down from some craziness.
So I had post about this on a Facebook group recently in a New Zealand growers group, where someone that claimed up and down that this isn't a real thing. In my opinion, it's how credible you believe science and medical science is, but this isn't anything new.
The earliest reported cases of Cannabis Hyperemesis Syndrome (CHS) were described in 2004 by Australian researchers Allen J. H., Allen et al. (2004) in the journal Gut, in a case series of 19 chronic cannabis users experiencing cyclical vomiting and abdominal pain, noting symptom relief with cannabis cessation and hot baths, highlighting its recent recognition in medical literature.
One of the most famous stories about CHS is Alice Moon, who if you've ever researched about this in the past few years, you probably know her story:
www.forbes.com
There is also a controversy over her story with Ethan Russo, a neurologist and psychopharmacologist, who go back and forth on the topic in a rather bitter debate over causation and correlation and criteria set for testing.
Quoted from the article:
“Ethan has more experience researching cannabinoids than almost anybody else. He’s been doing it for decades,” says Peter Grinspoon, a physician at Massachusetts General Hospital and an instructor at Harvard Medical School. Grinspoon describes Russo as “a leader” in the field, with “broad knowledge of both disease and cannabis.”
www.technologyreview.com
Cannabinoid Hyperemesis Syndrome is considered a real medical condition based on extensive clinical evidence, an identified set of diagnostic criteria (including the Rome IV criteria, which is a set of guidelines for diagnosing functional gastrointestinal disorders like irritable bowel syndrome (IBS) based on specific symptoms and their frequency), and a growing scientific understanding of its pathophysiology (the study of how a disease, injury, or other condition affects a patient, including both physical and functional changes.)
The World Health Organization (WHO) has added Cannabinoid Hyperemesis Syndrome to its diagnostic manual, based on guidance issued by the agency on October 1st, 2025. This now establishes a newly dedicated, standardized code for CHS called R11.16. The importance of this is that previously, clinicians had to use general codes for nausea and vomiting (like R11.2) along with a separate code for cannabis use.
The new designated ICD-10 code (ICD stands for International Classification of Diseases, 10th revision) represents a step forward in providing more definitive care for patients struggling with the syndrome.
The WHO employs over 8,000 public health experts, including scientists, doctors, and epidemiologists, who coordinate the world's response to health challenges.
Symptom reversal:
The most compelling evidence is the cyclical nature of symptoms shared among users reporting it. Patients find relief from nausea and vomiting only after ceasing cannabis use, and the symptoms return upon resuming it.
Unique symptom relief:
A key diagnostic feature is the compulsive need for hot showers or baths, which provides temporary relief from pain and nausea. This specific behavior is not typically associated with other vomiting syndromes.
Chronic cannabis use:
A history of long-term, often daily, cannabis use is a prerequisite for CHS. Studies show a strong link between early cannabis use and higher hospital visit rates for this syndrome.
Clinical data:
Research studies have documented cases of CHS, including one that found a significant increase in emergency department visits for the syndrome between 2017 and 2021 in North America, according to PBS.
There are numerous published papers and documentation found at the National Center for Biotechnology Information (considered a highly credible source of scientific and medical information and part of the National Institutes of Health (NIH) and the National Library of Medicine (NLM.) It's considered a respected and authoritative source for biomedical research and data, providing resources like PubMed which is widely used by scientists, medical professionals, and general public for reliable scientific information. Here are a few good reads on the topic:
https://www.ncbi.nlm.nih.gov/books/NBK549915/
Here's a great article from Frontiers:
https://www.frontiersin.org/.../ftox.2024.1465728/full
Here is a case report and review of pathophysiology for CHS from CM&R (Clinical Medicine and Research):
https://www.clinmedres.org/content/12/1-2/65
No one wants to admit this thing they love and enjoy that provides so many benefits could also have drawbacks. Pretending like there aren't drawbacks to cannabis is almost disgusting. Like who are we really defending or helping by ignoring science and data, the same science and data we praise and love when it's in our favorable spotlight?
Opponents of CHS claim that it's not real because the cause is still hypothetical.
The rebuttal to this is that from a scientific standpoint, something can be considered "real" even if the exact cause is unknown, because we can observe the effects of, use indirect inference, rely on probability, accept fundamental concepts, and demonstrate the reality of things through consistency of patterns, predictions, and interactions.
While the exact underlying mechanisms (referencing back to pathophysiology) are still being researched and debated, the clinical syndrome itself is well-documented in medical literature and the diagnostic criteria has been established.
The "hypothesis" is about HOW cannabis causes these symptoms, not whether or not these symptoms have been systematically observed and recorded (to which they have.)
In spirit of scientific theory, a scientific hypothesis can become real in the sense that it's strongly supported by evidence, but can also be potentially proven wrong (falsifiable), which is the very key to science (it's easy to put the blinders on when there is limited supporting evidence in the early stages of research.)
It's going to be through better research, studies, and trials that we'll be able to more accurately pinpoint why these things occur (not WHETHER they occur, because we KNOW they occur,) which will lead to more ACCURATE DIAGNOSIS by doctors, and less MISDIAGNOSIS by doctors, which I have found a number of patients have shared in their stories of being wrongly diagnosed with CHS when there were other underlying conditions.
So I had post about this on a Facebook group recently in a New Zealand growers group, where someone that claimed up and down that this isn't a real thing. In my opinion, it's how credible you believe science and medical science is, but this isn't anything new.
The earliest reported cases of Cannabis Hyperemesis Syndrome (CHS) were described in 2004 by Australian researchers Allen J. H., Allen et al. (2004) in the journal Gut, in a case series of 19 chronic cannabis users experiencing cyclical vomiting and abdominal pain, noting symptom relief with cannabis cessation and hot baths, highlighting its recent recognition in medical literature.
One of the most famous stories about CHS is Alice Moon, who if you've ever researched about this in the past few years, you probably know her story:
Weed Makes Me Throw Up: The Story Of Alice Moon, Her CHS, And The Hate She Gets For It
Cannabinoid hyperemesis syndrome (CHS), the mysterious illness triggered by marijuana use, and Alice Moon's experience with it.
www.forbes.com
There is also a controversy over her story with Ethan Russo, a neurologist and psychopharmacologist, who go back and forth on the topic in a rather bitter debate over causation and correlation and criteria set for testing.
Quoted from the article:
“Ethan has more experience researching cannabinoids than almost anybody else. He’s been doing it for decades,” says Peter Grinspoon, a physician at Massachusetts General Hospital and an instructor at Harvard Medical School. Grinspoon describes Russo as “a leader” in the field, with “broad knowledge of both disease and cannabis.”
The feud between a weed influencer and scientist over puking stoners
A scientist went looking for genes that cause cannabinoid hyperemesis syndrome. But a public spat with a cannabis influencer who suffers from the disease may have derailed his research.
My Personal Deep Dive
Real or Myth?
Cannabinoid Hyperemesis Syndrome is considered a real medical condition based on extensive clinical evidence, an identified set of diagnostic criteria (including the Rome IV criteria, which is a set of guidelines for diagnosing functional gastrointestinal disorders like irritable bowel syndrome (IBS) based on specific symptoms and their frequency), and a growing scientific understanding of its pathophysiology (the study of how a disease, injury, or other condition affects a patient, including both physical and functional changes.)
The World Health Organization (WHO) has added Cannabinoid Hyperemesis Syndrome to its diagnostic manual, based on guidance issued by the agency on October 1st, 2025. This now establishes a newly dedicated, standardized code for CHS called R11.16. The importance of this is that previously, clinicians had to use general codes for nausea and vomiting (like R11.2) along with a separate code for cannabis use.
The new designated ICD-10 code (ICD stands for International Classification of Diseases, 10th revision) represents a step forward in providing more definitive care for patients struggling with the syndrome.
The WHO employs over 8,000 public health experts, including scientists, doctors, and epidemiologists, who coordinate the world's response to health challenges.
Known replicable diagnostic evidence for CHS:
Symptom reversal:
The most compelling evidence is the cyclical nature of symptoms shared among users reporting it. Patients find relief from nausea and vomiting only after ceasing cannabis use, and the symptoms return upon resuming it.
Unique symptom relief:
A key diagnostic feature is the compulsive need for hot showers or baths, which provides temporary relief from pain and nausea. This specific behavior is not typically associated with other vomiting syndromes.
Chronic cannabis use:
A history of long-term, often daily, cannabis use is a prerequisite for CHS. Studies show a strong link between early cannabis use and higher hospital visit rates for this syndrome.
Clinical data:
Research studies have documented cases of CHS, including one that found a significant increase in emergency department visits for the syndrome between 2017 and 2021 in North America, according to PBS.
Science, Data, Studies, and Trials
There are numerous published papers and documentation found at the National Center for Biotechnology Information (considered a highly credible source of scientific and medical information and part of the National Institutes of Health (NIH) and the National Library of Medicine (NLM.) It's considered a respected and authoritative source for biomedical research and data, providing resources like PubMed which is widely used by scientists, medical professionals, and general public for reliable scientific information. Here are a few good reads on the topic:
https://www.ncbi.nlm.nih.gov/books/NBK549915/
Here's a great article from Frontiers:
https://www.frontiersin.org/.../ftox.2024.1465728/full
Here is a case report and review of pathophysiology for CHS from CM&R (Clinical Medicine and Research):
https://www.clinmedres.org/content/12/1-2/65
What do the opponents say?
"Oh, it can't possibly be real, because it didn't happen to me."
"It MUST be something else, it can't possibly be this thing that I enjoy doing."
"It's the use of all these pesticides and PGR's in unregulated cannabis."
"It MUST be something else, it can't possibly be this thing that I enjoy doing."
"It's the use of all these pesticides and PGR's in unregulated cannabis."
No one wants to admit this thing they love and enjoy that provides so many benefits could also have drawbacks. Pretending like there aren't drawbacks to cannabis is almost disgusting. Like who are we really defending or helping by ignoring science and data, the same science and data we praise and love when it's in our favorable spotlight?
Opponents of CHS claim that it's not real because the cause is still hypothetical.
The rebuttal to this is that from a scientific standpoint, something can be considered "real" even if the exact cause is unknown, because we can observe the effects of, use indirect inference, rely on probability, accept fundamental concepts, and demonstrate the reality of things through consistency of patterns, predictions, and interactions.
While the exact underlying mechanisms (referencing back to pathophysiology) are still being researched and debated, the clinical syndrome itself is well-documented in medical literature and the diagnostic criteria has been established.
The "hypothesis" is about HOW cannabis causes these symptoms, not whether or not these symptoms have been systematically observed and recorded (to which they have.)
In spirit of scientific theory, a scientific hypothesis can become real in the sense that it's strongly supported by evidence, but can also be potentially proven wrong (falsifiable), which is the very key to science (it's easy to put the blinders on when there is limited supporting evidence in the early stages of research.)
It's going to be through better research, studies, and trials that we'll be able to more accurately pinpoint why these things occur (not WHETHER they occur, because we KNOW they occur,) which will lead to more ACCURATE DIAGNOSIS by doctors, and less MISDIAGNOSIS by doctors, which I have found a number of patients have shared in their stories of being wrongly diagnosed with CHS when there were other underlying conditions.
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he said I was manic...
There were certain years on this forum dealing with you that now make a LOT of sense.
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Damn you sound more intelligent on this matter than all the Docs I've seen!Jean, I recall you mentioning this in the past... Holy crap man! What an ironic misery....
I feel some of the diagnostic waters may be muddied, considering how long you've been smoking. Any history of IBS or any other digestive disease? Anything pre-exisitng or co-emerged with the occurrence of CHS that could be a potential exacerbating factor to it is what's in my mind...
*(BTW, I corrected the name of the syndrome in your title, coz I'm technical like that
)...
Took the words right outta,...
I think you drilled the bullseye on this!
Jean, while it's just speculation on my part, I feel the epic amounts of long tern (over-)use have gone beyond just altering your endocannabinoid receptors and system on a more or less temporary basis. You may have whacked it out of "calibration" potentially permanently, or to the point of needing total use stoppage for years(?) and/or some sort of reparative therapy to help "reboot" it...?
As we know, this is pretty unexplored territory medically speaking, and so is the "fix"..
I think it's established science now that our bodies can and do adjust the amount of EC receptors, which is behind the increasing tolerance effect. Taken to extremes, who knows what happens, long and short term... What proverbial switches are getting thrown, on or off, for how long,...and the downstream consequences thereof...
I recall reading some medical info on microdosing a while back, and how the complex interactions between things are balanced on the razors edge... a little bit of this or that throws the switch in a positive direction, more does the opposite...
While THC has no LD50, it certainly does have a "toxicity effect" level,... And let's keep in mind all the other miscellaneous compounds going in as well-- (terp's, alkaloids, a host of other things that in tiny amounts are non-factors, but may not be in larger amounts... more X-factors to muddy the waters!)...
It's interesting that CBD isn't apparently an antagonist like THC is, but not surprising (granted the amounts consumed were nothing close to the same)...
It should be noted that CBD does not bind to/interact with the same receptors in the same way as THC does, in some ways they are very different animals... And it's likely the reason they work better medically together than either alone...
Thanks for the spelling correction. After all the OD battles you must know i can't spell and my grammar dont grammar lol.
Ive also had it diagnosed at
Cannabis Hypertension Syndrome not sure if that's the same beast or not. Possibly a mistake by the doc.
Good to know, and bummer deal at the same time. Like Waira was saying it could potentially take longer for things to heal up totally. If i have to quit for 6 months to a year to be able to go back to smoking a little and still feel good im OK with that. I get the mental health help though and not being able to stop.
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I was a H addict for almost 8 years up until about 10 years ago. Then to alcohol then finally clean/ only cannabis for the last 6 years or so. I wonder if my past drug abuse could be woven into this mess.
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Definitely medical.
Even if im using cannabis just for a buzz it's still medicinal for me because it's keeping me from other more dangerous things.
Ive had my med card now for going on 17 years. Got it prescribed for chronic pain, anxiety and depression.
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There were certain years on this forum dealing with you that now make a LOT of sense.
Twat....
..days......I couldn't take the prescription drugs..that is why I was put on the experimental treatment...
..They didn't stop the pain...but I didn't know who the hell I was at the end of the day...
.. personality altering.I came off all 3 treatments cold turkey....
..And..it was when I was in the UK.. BC.. before cannabis..
If the doctors gear had worked..
.. AFN would not exist..coz I wouldn't have turned to cannabis for my answers...Similar threads
