I personally don't. I use 100% coco. You can add perlite if you want but,I personally wouldnt do more than 80/20 coco/perlite. After it drains real good I give it another soak with ph water and cal mag until I see run off and then its good to go, no waiting needed.
Coco can be amended but imo its a lot more work. That's a personal decision you have to make man. I like to think of coco as soil (although it is wayyy different) I hand water my girls what I do is nutes on Monday and Friday every other day I give ph water with cal mag and maybe voodoo or koolbloom depending on the stage they are in. And about every other week I like to flush her real good with just PhD water. Then I go back to my routine. Again you have to find what works best with your genetics in your grow room. Hope this helps brother. Like I said coco is intimidating but it is the best medium I've ever used.