Cannabis Hyperemesis Syndrome

[Son of Hobbes]

The World Health Organization now officially recognizes CHS.

 

[Olderfart]

A quick thought…

There’s relatively little research done on this topic… but perhaps we can extrapolate some information on a well studied, and slightly related topic.

The impact of long term opioid abuse on the opioid receptors is well studied. There are changes the receptors go through with long term over exposure, in the bodies attempt at maintaining homeostasis. Perhaps a similar thing happens with the cb1 & cb2 receptors.

My suspicions precisely. However the question remains, why does this change in the receptors cause the symptoms, especially the unremitting puking? Does the opiod research discuss this aspect of the effect?

I use concentrate daily now, not all day, just eveniing and bedtime, so have been watching this issue carefully. Would be an absolute bugger, I hope I never see it.

 

[Frankthetank]

Does the opiod research discuss this aspect of the effect?

I’m not sure…

especially the unremitting puking?

Perhaps the vomiting is the mirror of the effect that alleviates nausea in a cancer patient that uses cannabis….

 

[grow_fetishist]

May I suggest reading the following research paper. It's more than 3 years old yet I rarely see it mention in related discussions online.

Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation - PubMed

<span><b>Background:</b> Cannabinoid hyperemesis syndrome (CHS) is a diagnosis of exclusion with intractable nausea, cyclic vomiting, abdominal pain, and hot bathing behavior associated with ongoing tetrahydrocannabinol (THC) exposure. Increasing cannabis use may elevate CHS prevalence...

pubmed.ncbi.nlm.nih.gov

Russo also has a dedicated site for it, but he also sells test kits there so I won't share that link. All the information is in the study anyway, just a bit more reading.

I'm fortunate enough to not have this problem (though of course other issues to deal with) and therefore have nothing to add to it.

I wish everyone well and minimal suffering.

 

[Frankthetank]

May I suggest reading the following research paper. It's more than 3 years old yet I rarely see it mention in related discussions online.

Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation - PubMed

<span><b>Background:</b> Cannabinoid hyperemesis syndrome (CHS) is a diagnosis of exclusion with intractable nausea, cyclic vomiting, abdominal pain, and hot bathing behavior associated with ongoing tetrahydrocannabinol (THC) exposure. Increasing cannabis use may elevate CHS prevalence...

pubmed.ncbi.nlm.nih.gov

Russo also has a dedicated site for it, but he also sells test kits there so I won't share that link. All the information is in the study anyway, just a bit more reading.

I'm fortunate enough to not have this problem (though of course other issues to deal with) and therefore have nothing to add to it.

I wish everyone well and minimal suffering.

I also found this update from the same author

https://pubmed.ncbi.nlm.nih.gov/39507417/

 

[Waira]

Jean, I recall you mentioning this in the past... Holy crap man! What an ironic misery....

I feel some of the diagnostic waters may be muddied, considering how long you've been smoking. Any history of IBS or any other digestive disease? Anything pre-exisitng or co-emerged with the occurrence of CHS that could be a potential exacerbating factor to it is what's in my mind...
*(BTW, I corrected the name of the syndrome in your title, coz I'm technical like that )...

Would you all consider yourselves medical or recreational users?


I’ve had dealings with folks with this issue in the past. I can’t remember ever hearing of a heavy medical user ever having it. I’m wondering if there’s something going on with continual, extreme overloading of an otherwise healthy endocannabinoid system.

The symptoms listed are essentially the things that the endocannabinoid system regulates (which are mood, sleep, appetite, memory and pain).

Essentially, I think what I’m getting at, is that the chronic overloading of the cannabinoid system with exogenous cannabinoids… is causing a disregulation event.

That’s just a theory I’ve had for awhile. I have no clue if it’s even on the right path, or not. But it’s input, I suppose…

Took the words right outta,...
I think you drilled the bullseye on this!

Jean, while it's just speculation on my part, I feel the epic amounts of long tern (over-)use have gone beyond just altering your endocannabinoid receptors and system on a more or less temporary basis. You may have whacked it out of "calibration" potentially permanently, or to the point of needing total use stoppage for years(?) and/or some sort of reparative therapy to help "reboot" it...?
As we know, this is pretty unexplored territory medically speaking, and so is the "fix"..

I think it's established science now that our bodies can and do adjust the amount of EC receptors, which is behind the increasing tolerance effect. Taken to extremes, who knows what happens, long and short term... What proverbial switches are getting thrown, on or off, for how long,...and the downstream consequences thereof...

I recall reading some medical info on microdosing a while back, and how the complex interactions between things are balanced on the razors edge... a little bit of this or that throws the switch in a positive direction, more does the opposite...
While THC has no LD50, it certainly does have a "toxicity effect" level,... And let's keep in mind all the other miscellaneous compounds going in as well-- (terp's, alkaloids, a host of other things that in tiny amounts are non-factors, but may not be in larger amounts... more X-factors to muddy the waters! )...

It's interesting that CBD isn't apparently an antagonist like THC is, but not surprising (granted the amounts consumed were nothing close to the same)...
It should be noted that CBD does not bind to/interact with the same receptors in the same way as THC does, in some ways they are very different animals... And it's likely the reason they work better medically together than either alone...

 

[Frankthetank]

Took the words right outta,...
I think you drilled the bullseye on this!

 

[Jean-O]

Hello yes i have cut out day time smoking and only have a couple of smokes in the evening where as before i was smoking all day and night it has helped but not totaly gone away. Some strains make it worse if they are to strong i find but i find if i smoke less deff better feeling health wise

Totally in the same boat my friend.
Have you ever tried a full 30 day detox?

 

[Jean-O]

Would you all consider yourselves medical or recreational users?


I’ve had dealings with folks with this issue in the past. I can’t remember ever hearing of a heavy medical user ever having it. I’m wondering if there’s something going on with continual, extreme overloading of an otherwise healthy endocannabinoid system.

The symptoms listed are essentially the things that the endocannabinoid system regulates (which are mood, sleep, appetite, memory and pain).

Essentially, I think what I’m getting at, is that the chronic overloading of the cannabinoid system with exogenous cannabinoids… is causing a disregulation event.

That’s just a theory I’ve had for awhile. I have no clue if it’s even on the right path, or not. But it’s input, I suppose…

Im a medical user , but also a recovering adict. Yes I believe overuse or overly potent extended use has something to do with this.
But over the last year I have reduced my use to very little consuming maybe a gram or 2 per day with symptoms reducing but not subsiding.
Im currently in day 7 of a 30 day detox, in hopes that purging my system or basically hitting the reset on my endocanabinoid system may possibly work as long as I dont over saturate it again.

 

[Del boy]

Totally in the same boat my friend.
Have you ever tried a full 30 day detox?

Hello jean-o i have gone 30 days smoke free as soon as i started smoking again back to the same weird stuff happening. But mental health went to shit wile not somking so the other side effects from weed are better then trashing my brain imo