I think it's long overdue to learn what commercial breeders/seed companies are doing in terms of real R&D. What are they doing or planning beyond using decades (or centuries?) old random luck-based manual pollination, crossing and growing-out of plants (vs. precise gene sequence and protein expression control and in vitro/cell culture technologies).These all sound like fantastic discussion points. I recently asked every breeder currently on-site (and a few off-site) to do an introductory Q&A style interview for the forum; perhaps some of these topics would be good follow-up interview questions for them. It would be interesting to fire off a sample set of questions to each one and see how each responds!
What is the degree to which breeders/seed companies have or are adopting now standard routine lab-based biotech industry technologies?
a) gene and protein sequencing;
b) bioinformatics and related AI/modeling; high throughput screening; metabolic pathway engineering, proteomics;
c) recombinant/genetic engineering/GMO technology [For ex., Agrobacterium-mediated and some viral vector-based plant-specific genetic engineering methods are now decades old and off-patent];
d) CRISPR, RNAi/antisense and other non-genetic modification methods of precise gene/protein expression control/editing;
e) in vitro/cell culture/fermentation methods (to internally develop new strains and for commercial- and home-scale cannabinoid manufacturing)
f) What about synthetic biology, enzymatic-based synthesis of cannabinoids?
Why aren't we being offered strains/seeds developed using modern, in some cases now even decades old, technologies? Is the lack of strain/seed patents simply making it not worthwhile to do R&D, or what's the problem? And if the current breeders/seed companies are not doing these things, who is?
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