hey man,
there's really up and downsides to both scenarios, i'll try my best to list as many as i can think of atm

firstly, genetics do play a part, especially for autos. for example, a "super auto" such as Auto Ultimate by Dutch Passions would definitely out-yield say a strain of auto that might be bred specifically to finish quickly. what strain were you thinking of growing?
back to the original comparison:
Scenario 1 - Single Photoperiod
- Low stress training(LST) would be needed to maximize yield by forming the desired plant structure.
- Veg time might be longer due to stress from LST and needing it to fill the screen before flowering iirc.
- Easier on your electricity bill
- More room for error, due to photoperiods generally being less fragile.
Scenario 2 - Few to several Autos
- Scrog still possible, wouldn't advise too much LST due to autos having a limited time to grow before flowering.
- More sensitive to nutes, have to be careful.
- No need to switch lighting timings/duration
- Strain plays a big part in yield
As for nutrients, I'm not too familiar with the Jungle Juice range, hopefully someone else might be able to shed some light. I'm currently using Advanced Nutrients, bit pricey but they seem to do the job really well. Edit: I forgot to add, I would advise getting some form of beneficial bacteria such as HydroGuard to help.
For oxygen, I'd say try to find out the output of the air pump you're planning on using, it'd be a better estimate e.g(a weak air pump with a ton of air stones wouldn't really work well.)
I'm using hydrotons(clay pellets) to surround my rockwool. You're right on that, they don't retain water very well; I try to pour the water at an angle so the bottom of the rockwool is wet, kinda encouraging the roots to grow downwards. I'm pretty sure it doesn't make much of a difference but just a habit lol.
P.S
Here's a link to a nice SCROG tutorial I refer to.
SCROG Tutorial