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Optic Foliar can be sprayed with the lights on. Apparently it's best to spray this as soon as your light comes on.I've tried foliar sprays it's best to do it at night with high powered LED lights. It can burn or etch the leafs even with just water it can leave spots everywhere. But over time I've found that spraying just after lights out worked best for me and left few to no spots anywhere. I'd be careful with that stuff may burn up your crop. But its good to test out and see what's the benefits is. Just my two cents for what it's worth. Peace
Disclaimer: I have never used a foliar spray.